WebJul 1, 2011 · It is likely that HSP70 contributes in several ways to the biology of tumors, including as a regulator of apoptosis and as a mediator of lysosome function and … WebOct 1, 2014 · PES (2-phenylethynesulfonamide), also named pifithrin-μ, was first identified as a compound able to repress apoptosis induced by the translocation of p53 to the …
HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide …
WebPifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. … WebTraductions en contexte de "N-méthoxy" en français-anglais avec Reverso Context : Lorsqu'un carbone nucléophile (réactif de Grignard ou organolithien) réagit avec cette amide de Weinreb, le métal est chélaté par les oxygènes du carbonyle et du groupe N-méthoxy, empêchant de nouvelle additions nucléophiles. hornby curved track
2-phenylethynesulfonamide inhibits growth of oral …
WebJun 2, 2011 · One recently identified inhibitor is 2-phenylethynesulfonamide, here referred to as "PES" . PES (also called phenylacetylenylsulfonamide or pifithrin-mu) was originally identified in a screen for molecules that would impair the mitochondrial localization of p53 . Our previous work on PES revealed that it acts as a direct inhibitor of the stress ... WebJan 1, 2024 · The small molecule 2-phenylethynesulfonamide (PES) was originally identified as the inhibitor of p53 effects on the mitochondrial death pathway. In this report we demonstrate that p53 protein from PES-treated cells was detected in reduced mobility bands between molecular weights 95–220 kDa. Resolution of p53 aggregates on urea gel was … WebHuang C, Wang J, Chen Z, Wang Y, Zhang W (2013) Morton CL, Kolb EA et al. (2012) Initial testing (Stage 1) of 2-phenylethynesulfonamide prevents induction of pro- AT13387, an HSP90 inhibitor, by the pediatric preclinical inflammatory factors and attenuates LPS-induced liver injury testing program. hornby curved platform