Web16 okt. 2024 · The epithelial-to-mesenchymal transition (EMT) plays a prominent role in cancer metastasis. Isoliquiritigenin (ISL), one of the flavonoids in licorice, has been shown to exhibit anticancer activities in many cancer types through various mechanisms. However, it is unknown whether ISL impacts the EMT process. Here, we show that ISL is able to … Web12 apr. 2024 · Cells in the mesenchymal state then regain epithelial features and this process has been termed mesenchymal to epithelial transition (MET). This reversal of EMT is deemed imperative to establish a tumor in secondary sites during metastasis, a phenomenon termed as ‘reseeding’.
Molecules Free Full-Text Isoliquiritigenin Inhibits Ovarian Cancer ...
WebEpithelial-mesenchymal transition (EMT) refers to a process by which epithelial cells change into mesenchymal stem cells with an increase in migratory and invasive … WebHowever, an effective anticancer drug that directly targets EMT has not yet been discovered. Therefore, we aimed to investigate the repressive effects of bovine lactoferrin (bLF) on EMT to achieve mesenchymal-to-epithelial transition (MET) in OSCC. OSCC cell lines, HOC313 (EMT-induced) and SCCVII (without EMT induction), were treated with bLF. day brook village nursing center
The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal …
WebMost notably, we discovered that HCMV inhibits epithelial-to-mesenchymal transition (EMT) gene expression. EMT inhibition was accompanied by mesenchymal-to-epithelial transition (MET) gene induction in primary cells. Infection of mesenchymal cancer cells with HCMV similarly inhibited EMT gene expression and induced MET. Web1 jul. 2024 · Hence, understanding the biology of EMT and the reverse mesenchymal-to-epithelial transition (MET) process should lead to the design of more effective drugs to … WebEpithelial-mesenchymal transition (EMT) and the reverse process, mesenchymal-epithelial transition (MET), are essential during development and in the regulation of stem cell pluripotency, yet these processes are also activated in pathological contexts, such as in fibrosis and cancer progression. In EMT and MET, diverse signaling pathways ... gatsby athens greece