Cisplatin kidney function

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August undefined, 2024

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). WebCisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, …

Cisplatin: Package Insert - Drugs.com

WebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National … Cisplatin for injection, USP: single-dose vials containing 50 mg of Cisplatin as white to light yellow lyophilized powder for reconstitution. See more Cisplatin for injection is contraindicated in patients with severe hypersensitivity to Cisplatin [see Warnings and Precautions (5.4)]. See more little darlings 1980 movie cast

Drug-Induced Nephrotoxicity AAFP

WebFeb 1, 2016 · Cisplatin, a commonly used cancer chemotherapeutic, has a dose-limiting side effect of nephrotoxicity. Approximately 30% of patients administered cisplatin suffer from kidney injury, and there are limited treatment options for the treatment of cisplatin-induced kidney injury. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebSep 1, 2014 · Acute kidney injury (AKI), previously called acute renal failure (ARF) , is defined as an abrupt onset of renal dysfunction ranging from minor loss of function to failure [7,8,9]. AKI is a common clinical complication that develops in approximately 4%–7% of hospitalized patients each year and the prognosis can be poor [ 10 , 11 ]. little darlings 1980 cast

Exploring the Metabolic Differences between Cisplatin- and UV …

cisplatin and kidney dysfunction — Cancer Survivors Network

WebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. WebAug 15, 2024 · Among nephrotoxic agents that cause AKI, cisplatin is a chemotherapeutic drug that has been extensively used for treating solid cancers including breast, pancreatic, colorectal, esophageal, blood, lung, bladder, and hepatocellular cancers (Holditch et al., 2024; Rottenberg et al., 2024). little darlings 1980 plotWebcisplatin; kidney toxicity; redox imbalance; mitochondria; natural products; oxidative stress 1. Introduction Cisplatin is a widely used anti-solid tumor drug that can target a variety of cancers including those of the breast, ovary, lung, testis, head, and neck [ 1, 2, 3, 4, 5 ]. little darling sheet music

"WebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. " - Cisplatin kidney function

Cisplatin kidney function

Developing better mouse models to study cisplatin-induced kidney …

WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … WebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases.

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WebOct 14, 2024 · Cisplatin is an inorganic platinum-based drug that was FDA approved as an anticancer agent in 1978.1It is a standard therapy used to treat many solid organ cancers.2The major mechanism of action of cisplatin involves binding DNA and forming adducts, leading to apoptosis or cell cycle arrest. WebAbstract Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney …

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebMar 1, 2024 · Acute kidney injury (AKI) is the main obstacle that limits the use of cisplatin in cancer treatment. Proton pump inhibitors (PPIs), the most commonly used class of medications for gastrointestinal complications in cancer patients, have been reported to cause adverse renal events. However, the effect …

WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al ... WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative …

WebJan 12, 2011 · Since its introduction into clinical trials, cisplatin (cis-diammine-dichloro-platinum) has had a major impact in cancer medicine, changing the course of therapeutic management of several tumors, such as those of ovary, testes, and the head and neck.

WebRenal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin. little darlings night clubWebNov 11, 2024 · Cisplatin (CDDP), a platinum drug, has been universally utilized to treat bladder cancer, ovarian cancer and other solid tumors ( Dasari and Tchounwou, 2014 ). However, the dominant factor restricting the clinical use of cisplatin is its nephrotoxicity ( Zhu et al., 2015 ). little darlings las vegas yelpWebFeb 14, 2024 · Nevertheless, 40–50% of patients have impaired renal function that precludes the use of cisplatin. The non-nephrotoxic platinum analogue, carboplatin, has … little darlings daycare mount laurelWebFeb 16, 2024 · Common side effects of cisplatin may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is … little darlings new orleansWebJun 18, 2024 · The current use of cisplatin in regimens involving pre and posthydration with careful monitoring of diuresis in the treatment of testicular tumors is associated with renal … little darlings movie castWebApr 25, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … little darlings nursery newportWebJun 11, 2024 · Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration Scientific Reports Article Open Access Published: 11 June 2024 Vagus... little darling woodland animal fabric